Rutas metabolicas PDF

Preview

Summary

Warning: Unimplemented annotation type "FreeText", falling back to base annotation. Warning: Unimplemented annotation type "FreeText", falling back to base annotation. Warning: Unimplemented annotation type "FreeText", falling back to base annota...

Description

Enzymes available from Sigma

OXIDOREDUCTASES 1.1.1.1฀ Alcohol dehydrogenase 1.1.1.3 ฀ Homoserine dehydrogenase 1.1.1.8฀ Glycerol-3-phosphat e dehydrogenase 1.1.1.9฀ D-Xylulose reduct ase 1.1.1.10฀ l-Xylulose reduct ase 1.1.1.14฀ l-Idit ol dehydrogenase 1.1.1.19฀ Glucuronat e reduct ase 1.1.1.21฀ Aldehyde reduct ase 1.1.1.22฀ UDPglucose dehydrogenase 1.1.1.23฀ Hist idinol dehydrogenase 1.1.1.25฀ Shikimat e dehydrogenase 1.1.1.27฀ Lact at e dehydrogenase 1.1.1.29฀ Glycerat e dehydrogenase 1.1.1.30฀ 3-Hydroxybut yrat e dehydrogenase 1.1.1.31฀ 3-Hydroxyisobut yrat e dehydrogenase 1.1.1.32฀ Mevaldat e reduct ase 1.1.1.34฀ Hydroxymet hylglut aryl-CoA reduct ase (NADPH) 1.1.1.35฀ 3-Hydroxyacyl-CoA dehydrogenase 1.1.1.37฀ Malat e dehydrogenase 1.1.1.39฀ Malat e dehydrogenase (decarboxylat ing) 1.1.1.41฀ Isocit rat e dehydrogenase (NAD+) 1.1.1.44฀ Phosphogluconat e dehydrogenase ฀ (decarboxylat ing) 1.1.1.45฀ l-Gulonat e dehydrogenase 1.1.1.49฀ Glucose-6-phosphat e dehydrogenase 1.1.1.56฀ Ribit ol dehydrogenase 1.1.1.79฀ Glyoxylat e reduct ase (NADP+) 1.1.1.81฀ Hydroxypyruvate reduct ase 1.1.1.82฀ Malat e dehydrogenase (NADP+) 1.1.1.85฀ 3-Isopropylmalat e dehydrogenase 1.1.1.86฀ Ket ol-acid reduct oisomerase 1.1.1.95฀ Phosphoglycerat e dehydrogenase 1.1.1.100฀ 3-Oxoacyl-[acyl-carrier-prot ein] reduct ase 1.1.1.102฀ 3-Dehydrosphinganine reduct ase 1.1.1.105฀ Ret inol dehydrogenase 1.1.1.130 ฀ 3-Dehydro-L-gulonat e 2-dehydrogenase 1.1.1.157฀ 3-Hydroxybut yryl-CoA dehydrogenase 1.1.1.158฀ UDP-N-acet ylmuramat e dehydrogenase 1.1.1.169฀ 2-Dehydropant oat e 2-reduct ase 1.1.1.204฀ Xant hine dehydrogenase 1.1.1.205฀ IMP-dehydrogenase 1.1.3.8฀ l-Gulonolact one oxidase 1.1.3.22฀ Xant hine oxidase 1.1.99.1฀ Choline dehydrogenase 1.1.99.5฀ Glycerol-3-phosphat e dehydrogenase 1.2.1.3฀ Aldehyde dehydrogenase (NAD+) 1.2.1.7฀ Benzaldehyde dehydrogenase (NADP+) 1.2.1.8฀ Bet aine-aldehyde dehydrogenase 1.2.1.11฀ Aspart at e-semialdehyde dehydrogenase 1.2.1.12฀ Glyceraldehyde-3-phosphat e dehydrogenase 1.2.1.13฀ Glyceraldehyde-3-phosphat e dehydrogenase 1.2.1.16฀ Succinat e-semialdehyde dehydrogenase (NAD(P)+) 1.2.1.18฀ Malonat e semialdehyde dehydrogenase ฀ (acet ylat ing) 1.2.1.21฀ Glycolaldehyde dehydrogenase 1.2.1.23฀ 2-Oxoaldehyde dehydrogenase (NAD+) 1.2.1.24฀ Succinat e-semialdehyde dehydrogenase 1.2.1.25฀ 2-Oxoisovalerat e dehydrogenase (acylat ing) 1.2.1.27฀ Met hylmalonat e-semialdehyde ฀ dehydrogenase (acylat ing) 1.2.1.31฀ l-Aminoadipat e-semialdehyde dehydrogenase 1.2.1.32฀ Aminomuconat e-semialdehyde dehydrogenase 1.2.1.36฀ Ret inal dehydrogenase 1.2.1.41฀ Glut amat e-5-semialdehyde dehydrogenase 1.2.1.52฀ Oxoglut arat e dehydrogenase 1.2.3.5฀ Glyoxylat e oxidase 1.2.3.7 ฀ Indole-3-acet aldehyde oxidase 1.2.4.1฀ Pyruvat e dehydrogenase (lipoamide) 1.2.4.2฀ Oxoglut arat e dehydrogenase (lipoamide) 1.2.7.1฀ Pyruvat e synt hase 1.2.7.2฀ 2-Oxobut yrat e synt hase 1.3.1.1฀ Dihydrouracil dehydrogenase (NAD+) 1.3.1.2฀ Dihydropyrimidine dehydrogenase (NADP+) 1.3.1.8฀ Acyl-CoA dehydrogenase (NADP+) 1.3.1.9฀ Enoyl-[acyl-carrier-prot ein] reduct ase (NADH) 1.3.1.10฀ Enoyl-[acyl-carrier-prot ein] ฀ reduct ase (NADPH, B-specific) 1.3.1.13฀ Prephenat e dehydrogenase (NADP+) 1.3.1.14฀ Orot at e reduct ase (NADH) 1.3.1.26฀ Dihydrodipicolinat e reduct ase 1.3.1.35฀ Phosphat idylcholine desat urase 1.3.3.3฀ Coproporphyrinogen oxidase 1.3.3.4฀ Prot oporphyrinogen oxidase 1.3.5.1฀ Succinat e dehydrogenase (ubiquinone) 1.3.99.1฀ Succinat e dehydrogenase 1.3.99.2฀ But yryl-CoA dehydrogenase 1.3.99.3฀ Acyl-CoA dehydrogenase 1.3.99.7฀ Glut aryl-CoA dehydrogenase 1.3.99.10฀ Isovaleryl-CoA dehydrogenase 1.4.1.1฀ Alanine dehydrogenase 1.4.1.2฀ Glut amat e dehydrogenase 1.4.1.7฀ Serine dehydrogenase 1.4.1.8฀ Valine dehydrogenase (NADP+) 1.4.1.9฀ Leucine dehydrogenase 1.4.1.10฀ Glycine dehydrogenase 1.4.1.14฀ Glut amat e synt hase (NADH) 1.4.1.19฀ Trypt ophan dehydrogenase 1.4.3.1฀ d-Aspart at e oxidase 1.4.3.2฀ l-Amino-acid oxidase 1.4.3.4฀ Amine oxidase (flavin-cont aining) 1.4.3.8฀ Et hanolamine oxidase 1.4.4.2฀ Glycine dehydrogenase (decarboxylat ing) 1.5.1.2฀ Pyrroline-5-carboxylat e reduct ase 1.5.1.3฀ Dihydrofolat e reduct ase 1.5.1.5฀ Met hylenet et rahydrofolat e reduct ase (NADP+) 1.5.1.6฀ Formylt et rahydrofolat e dehydrogenase 1.5.1.7฀ Saccharopine dehydrogenase (NAD+, ฀ l-lysine-forming) 1.5.1.8฀ Saccharopine dehydrogenase (NADP+, ฀ l-lysine-forming) 1.5.1.9฀ Saccharopine dehydrogenase (NAD+, ฀ l-glut amat e-forming) 1.5.1.10฀ Saccharopine dehydrogenase (NADP+, ฀ l-glut amat e-forming) 1.5.1.12฀ 1-Pyrroline-5-carboxylat e dehydrogenase 1.5.3.1฀ Sarcosine oxidase 1.5.99.1฀ Sarcosine dehydrogenase 1.5.99.2฀ Dimet hylglycine dehydrogenase 1.5.99.8฀ Proline dehydrogenase

P O L Y S A C C H A R I D E S

BLOOD GROUP HYALURONIC ACID DERMATAN SUBSTANCES PEPTIDOCHONDROITIN PECTIN GLYCAN CH OHCHITIN

GLYCOPROTEINS GANGLIOSIDES MUCINS

2

AcNH

CHOH CHOH

O

O CO O-

6.3.2.7-10 HO O 6.3.2.13

2.4.99.7

CH2OH

O COO -

OPC

OPPU

CH3 CH

CMP-N-Acetyl neuraminate

CH2 OH O COO HO

O

OH OH 2.7.7.43

1.1.1.158

3.1.3.29

N-Ac-Neuraminate

HO O CH2 C

(Sialate)

CH2 OP O

OPPU

HO

CH 2OH O

CH2 OH O

2.7.1.60 ACNH HO OH

HO OH

OH

HO OH

OH

H

H

C

C

OH H

H

3.1.1.18 HOCH2

OH OH C

CO

OH

HOCH2 C H

C

HOCH2 C H

C

H

-

CHO

HOCH2

C OH

OH H

H

C

H

C

H

H

OH

C

C

C

CHO

HOCH 2

1.1.1.10

CHO

HOCH2

C

H

OH H

C

C

C

OH H

C

C

H

H

OH OH

C

C

C

C

CO CH 2OH

C

C

CO

OH

POCH2

CH 2OH

C

H

OH

HOCH2

H

OH H

C

C

C

HOCH2

H

H

H

C

C

C

C

C

H

H

OH

C

C

OH

C

C

H

OH H

C

C

C

H HOCH2

C COO-

6-P-Gluconate NADPH OH

CO

NADP +

CH2 OP

1.1.1.44

POCH2

C

C

CO CH2 OH

OH OH

C

H C

2H+

C

Ferredoxin

5.1.3.1

CHO

5.3.1.6 POCH2

P680

2H2O

O2

e-

CH2 OH

2. 7. 1. 15

ATP

CO CH 2OH

4.1.2

H H C

H

C C

CHO

POCH2

Sedo

4.1.2.13

ADP+Pi 3H+

2e*

HOCH2 CO CH 2O P

2H+ PC

PC 3H+ 2H+ Tr P700 n s H an sl oc ate d pr o to H H +

+

+

H

H

+

+

(Glycerone- P)

+ NADP HOCH 2CH(OH)CH

+

H

H+ H+ H+

NADPH+H

+

H H+

2

Dihydroxy acetone-P

3.6.1.3

f

Thylakoid Lumen

C

D-Ribose-5-P

PQH2

2H +

OH

C

D-Xylulose-5-P 2.7.1.17

Cyt.

Thylakoid Membrane

H

OH OH OH

b

Mn

Eryth

OH OH OH

D-Ribose

3.6.1.34

2e*-

PQ

POCH2

H

POCH2

Chlorophyll Pheophytin

NADPH

5.1.3.1

OH H

CO

OH H

PHOTOSYSTEM II

O

P-G la

7 .1.1 3.1

H H

5.1.3.4

D-Xylulose

Chloroplast Stroma PHOTOSYSTEM I

HO OH

1.4

D-Ribulose-5-P

CO CH OH 2

H

H

CH 2OH

Ribitol

L-Ribulose 2.7.1.16 L-Ribulose-5-P HOCH2

H

C

OH

D-Xylose POCH2

H

OH OH OH

CHO

2.7 .

2.7.1.3

OH OH H

HOCH2

CH2 OH

OH

OH OH H

CO CH 2OH

CH2 O

C

Sorbitol

O

2.7.1.47

OH OH

1.1.1 .9

C

Fructose-1-P

C

OH H

CO CH2 OH

C

OH OH H

POCH2

L-Xylulose-5-P

2.7.1.47

HOCH2 C

Dehydroascorbate

D-Ribulose

2.7.1.53

OH H

CO

CO CH2 OH

3.2

5.5.1.4 H

1.10.3.3 CO

H

C

SUCROSE

H

1.1.1.14

CO

O

HOCH2

OH OH

5.3.1.3

OH OH HOCH 2

OH OH

OH H

OH H

CO COO -

CO

CO CH 2OH

OH

Xylitol

.4

2e*

2.3.1 .4 5.3.1.8

Fructose

OH

H H

L-Xylulose

L-Lyxose

P H O T O S Y N T H E S

2.4.1

2.4.1.9

Inositol-P

OH H

C

H

CHO

HOCH2

H

OH

C

HOCH2 C

CH2 OH

H

C

OH NHCOCH 3

ASCORBATE 1.10.2.1

OH H

L-Arabinose 5.3.1 HOCH2 C

CO

OH

D-Arabinose

OH OH H C

C

OH OH H

L-Arabitol H

CO

H

H

C

OH OH

H

C

2, 3-Dioxogulonate

H

HOCH2 C

OH

C

HOCH2 C

1.1.1.130

4.1.1.34 C

HOCH2

OP

3.1.3.25

Inositol

OH H

C COO

OH H

OH H

C

OH

1.13.99.1

O

H

L-Xylose

Mannose-6-P

N-Ac-Glucosamine-6-P

OH

HO OH

2-Oxogulonolactone

OH

C

OH

OH

H

3-Dehydrogulonate OH H

HOCH2

OH

C

HO OH

5.4.2.3

N-Ac-Glucosamine-1-P OH

HO OH

OH OH

H

OH H

H

OH

Glucuronate

CO

O

HOCH2 C

HO OHHO OH

CH2 OP O

NHCOCH 3

OH

OH H

C

Gulonolactone1.1.3.8 1.1.1.45

TDP-Gluc

CH 2O P O

OH OH H

1.1.1.19

H

1

2.7.7.23

HO

OH H

H

4.2.1.46

2.7.1.7

5.4.2.8

OP

HO OH

UDP-N-Ac- Glucosamine

C

C

MANNOSE

2.7.7.13

OH HO O P

CH 2OH O

OPPU

COO-

Gulonate

CH 2OH O

UDP-Glucuronate

4.1.3.20

OH OH

C

HO OH HO OH

5.1.3.6

OPPU OH

O C

TDP-46-deoxyg

GDP-Mannose

Mannose-1-P

COO OH

CH2 OH O

OPPU

5.1.3.7

5.1.3.14

HOCH2

O

UDPGalacturonateHO

NHAC

N-Ac-Mannosamine

OH

2.4.1.33

HO OH HO OPPG

OH

O

UDP-N-AcGlucosamine pyruvate N-Ac-Mannosamine-6-P

P E N T O S E S

OPPU

NHAC

CH

5.1.3.13 O

4.2.1.47 COO-

COO

3.1.3.29 ACNH 4.1.3.20 HO OH OH

H E X O S E S

5.1.3.12

COO

TDP-Rham

GDPGDP-Fucose Mannuronate CH2 OH O

UDP-N-AcGalactosamine

HO

OH

HO OPPG

OH

NHCOCH 3

CH2 OH O

O

HO

2.4.1.16

COO

CE HO CH3

CH3

OH

UDP-N-Ac-Muramate

CHOH CHOH CH2 OH

OPPU

O-ANTIGEN

INULIN 1.1.1.132

2.4.1.68 2.4.1.69

UDPIduronate

COO-

HO

AcNH

HO OH

2.4.1.17

NHAC

ALGINATES

H

H

POCH2 C

C

CO

CH2 OP

+

Glyceraldeh CH2

2761...