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Other name of Ferric ammonium sulfate a. Ferric alum b. Fe NH 4 (SO 4 ) 2 c. Fe (NH 4 ) 2 (SO 4 ) 2 d. A and B e. A and C The following is/are example/s of metal-ion indicators. I. Murexide II. Calmagite III. Pyrocathecol violet IV. Ferric alum a. I only b. I and II only c. I, II, and III d. I, II, ...

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Quality Control and Quality Assurance Questions [PINK PACOP] 1. Other name of Ferric ammonium sulfate a. Ferric alum b. Fe NH4 (SO4)2 c. Fe (NH4)2(SO4)2 d. A and B e. A and C 2. The following is/are example/s of metal-ion indicators. I. Murexide III. Pyrocathecol violet II. Calmagite IV. Ferric alum a. I only b. I and II only c. I, II, and III d. I, II, III and IV 3. Assay of diluted HCl is expressed in: a. % w/w b. % w/v c. Both a and b d. None of the choices 4. Standard solution in precipitation method od analysis a. Disodium edetate b. Silver nitrate c. Sodium Methoxide d. Perchloric acid 5. Use to prevent one element from interfering in the analysis of another element a. Masking agent b. Demasking agent c. Both a and b d. None of the choices 6. Argentometric titration is titration with ______ ion. a. Magnesium b. Sodium c. Silver d. Potassium 7. Fajans titration uses ____ indicator. a. Acid-base b. Adsorption c. Metal-ion d. None of the choices 8. Reasons why residual titration are performed. a. Reaction proceeds slowly b. Poor solubility of the sample c. Sample does not give sharp end point d. All of the choices Page 1 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] 9. Solutions containing all the reagents and solvents used in the analysis, but no deliberately added analyte. a. Blank solution b. Solution with sample c. Standard solution d. Test solution 10. Describes how close a measured value is to the true value. a. Accuracy b. Precision c. Range d. Standard deviation 11. Primary standard in the standardization of perchloric acid a. Potassium hydrogen phthalate b. Calcium carbonate c. Benzoic acid d. Sodium carbonate 12. Primary standard in the standardization of sodium methoxide. a. Benzoic acid b. Sodium bicarbonate c. Sodium carbonate d. Potassium hydrogen phthalate 13. The term dried to constant weight means that two consecutive weighing do not differ by more than: a. 0.0002 g b. 0.2 mg c. 0.5 mg/g d. All of the choices e. C only 14. Other name of systematic error a. Determinate b. Indeterminate c. Random d. Both b and c 15. Ferric ammonium sulfate is used as indicator in the standardization of: a. Silver nitrate b. Ammonium thiocyanate c. Edetate disodium d. All of the choices 16. The end point of using number ferric ammonium sulfate is: a. White precipitate b. Red-brown color c. Pink color d. Blue color 17. Limit moisture in nonaqueous titrimetric analysis is less than: Page 2 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] a. 0.5 % b. 0.05 % c. 0.2 % d. 0.02 % 18. Complete reaction: H2C4H4O6 + NaOH - a. Na2C4H4O6 b. H2O c. Both a and c d. None of the choices 19. A ligand that binds to a metal ion through only one atom. a. Monodentate b. Bidentate c. Tridentate d. Tetradentate 20. Which of the following is added to maintain the pH of sodium thiosulfate in optimum range for the stability of the solution? a. Sodium bicarbonate b. Chloroform c. Thymol d. Sodium carbonate 21. Standard solution in non-aqueous titrimetric analysis-acidimetry a. perchloric acid b. hydrogen bromide c. both a and b d. none of the choices 22. Standards solutions are also known as: a. test solutions b. volumetric solutions c. saturated solution d. none of the choices 23. If starch is used as an indicator, the end point is/are: a. appearance of intense blue color b. disappearance of intense blue color c. both of the choices d. none of the choices 24. Types of chemical reaction used in the volumetric analysis a. redox b. neutralization c. diazotization d. all of the choices e. a and b only 25. Use of KI in the preparation of iodine solution. a. Solubilizing agent b. Change in pH of the solution Page 3 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] c. As preservative d. All of the choices 26. Other name of ferrous phenanthroline. a. eosin Y b. crystal violet c. ferroin d. ferric alum 27. Color of the complex resulting from reaction with ferrous phenanthroline: a. blue b. red c. pink d. violet 28. Primary standard in the standardization of ceric sulfate solution a. potassium hydrogen phthalate b. calciuim carbonate c. sodium bicarbonate d. arsenic trioxide 29. In the standardization of iodine solution, why is there a need to boil the solution of arsenic trioxide? a. it increases the solubility b. it makes the solution stable c. both a and c d. none of the choices 30. Indicator in iodometric method of analysis. a. KMnO4 b. Methyl red TS c. Methyl orange TS d. Starch TS 31. A molecule which provides groups of attachment to metal ions. a. Ligand b. Chelate c. Both a and b d. None of the choices 32. HCl + Calcium carbonate will react to form a primary product known as: a. Carbonic acid b. Calcium hydroxide c. Both a and c d. None of the choices 33. The reaction between HCl and calcium carbonate can be seen in the standardization of: a. Silver nitrate b. Ammonium thiocyanate c. Edetate disodium d. Sulfuric acid 34. A substance which gains electrons in a redox reaction. Page 4 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] a. Oxidizing agent b. Reducing agent c. Both a and c d. None of the choices 35. The equilibrium constant for the reaction of the metal ion with a ligand is called _____. a. Formation constant b. Solubility product constant c. Solubility constant d. None of the choices 36. NaCl ______ the stability of EDTA complex. a. Increases b. Decreases c. No effect d. None of the choices 37. Organic solvents _______ the stability of EDTA complex. a. Increases b. Decreases c. No effect d. None of the choices 38. Indicator in Redox Titration using KMnO4 a. Starch TS b. KMnO4 c. Methyl red TS d. Methyl orange 39. Developed in 1883, this method of analysis remains as one of the accurate and widely used method for determining nitrogen in substance. a. Non-aqueous titrimetry b. Precipitation c. Redox itration d. Kjeldahl method 40. Most suitable indicator to use in titration of organic acids a. Methyl red TS b. Methyl orange TS c. Phenolphthalein d. All of the choices 41. Which of the following statement/s is/are correct? I. Non-aqueous alkalimetry is used when the analyte is weakly acidic II. Non-aqueous alkalimetry is used when analyte is acid halide. III. Non-aqueous alkalimetry is used when the analyte contains heterocyclic nitrogen compound. IV. Non-aqueous alkalimetry is used when analyte is barbiturate. a. I only c. I, II, and III only b. I and II only d. I, II, and IV 42. Indicator/s used in nonaqueous titrimetry Page 5 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] I. II. III. IV.

Nile blue Crystal violet Malachite green Phenolphthalein a. I only c. I, II, and III only b. I and II only d. I, II, III and IV 43. Standard solutions in nonaqueous alkalimetry. I. Lithium methoxide II. Perchloric acid III. Hydrogen bromide IV. Sodium hydroxide c. I, II, and III only a. I only b. I and II only d. I, II, III and IV 44. The use of chloroform in sodium thiosulfate solution. a. To stabilize the solution b. To increase its solubility c. To prevent bacterial growth d. To maintain pH of the solution 45. Which of the following statement/s is/are correct? I. The utility of starch as indicator is reduced in the presence of organic solvent. II. The utility of starch as indicator is reduced in the presence of electrolytes. III. The utility of starch as indicator is reduced at temperature above 25 °C IV. The utility of starch as indicator is reduced at temperature of 25°C. a. I only b. I and II only c. I, II, and III d. I, II, III and IV 46. When a weak base is to be titrated with weak acid, the indicator used is: a. Phenolphthalein b. Methyl orange c. Methyl red d. No indicator is suggested 47. The formula to compute the equivalent weight of a reducing agent. a. Molecular weight/ no. of electrons gain b. Molecular weight/ no. of electrons loss c. Both a and b d. None of the choices 48. The used of sodium bicarbonate in the standardization of iodine solution ______. a. Increase the solubility b. as buffer c. As preservative d. To prevent bacterial growth 49. Method/s determining the total nitrogen in a sample Page 6 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] a. Macromethod b. Semimicro method c. Both a and c d. None of the choices 50. To keep samples moisture free, the appropriate apparatus to use is: a. Desiccator b. Separatory funnel c. Furnace d. Incubator 51. The following is/are true about EDTA: I. EDTA forms strong 1:1 complexes with most metal ions. II. It prevents metal-catalyzed oxidation of food. III. It is a pentadentate molecule IV. It contains 3 oxygen and 2 hydrogen atoms that are capable of entering complexation reaction with metal ion. a. I only b. I and II c. II and III d. III and IV 52. Sulfamic acid (H3NSO3) is a primary standard that can be used to standardized sodium hydroxide. What is the molarity if 33.26 mL reacts with 0.3337 g sulfamic acid. MW=97 a. 0.304 b. 0.1004 c. 0.1005 d. 0.403 53. A 0.2185 g sample of NaCl was assayed using Volhard method using 50 mL of 0.998N silver nitrate and 11.9 mL of 0.1350N ammonium thiocyanate. Calculate the NaCl in the sample. MW NaCl = 58.45 a. 42.6 b. 62.4 c. 90.5 d. 6.24 54. A 4.59 mL sample of HCl, specific gravity 1.3, required 50.5 mL of 0.9544N NaOH in a titration. Calculate the % w/w HCl. a. 29% b. 1% c. 92% d. 69% 55. What is the titer value for 0.05 M calcium chloride with 2 moles of water? MW= 142.9 a. 3.57 mg b. 7.15 mg c. 73.5 mg d. 53.7 mg Page 7 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] 56. A 10 mL sample of sulfuric acid solution required 16.85 mL of NaOH solution in a titration. Each mL of the NaOH solution was equivalent to 0.2477 g of potassium hydrogen phthalate. Calculate the sulfuric acid content in %w/v. MW=98 a. 10% b. 20% c. 30% d. 40% 57. Limestone consists mainly of the mineral calcite, CaCO3. The carbonate content of 0.5413 g of powdered limestone was measured by suspending the powder in water, adding 10 mL of 1.392 M HCl and heating to dissolve the solid and expel CO2. The excess acid required 39.96 mL of 0.1004 M NaOH for complete titration to a phenolphthalein end point. Find the weight % of the calcite in the limestone. MW=100 a. 29% b. 39% c. 92% d. 96% 58. The Kjeldahl procedure was used to analyzed 256µL of a solution containing 37.9 mg protein/mL. The liberated ammonia was collected in 5 mL of 0.0336 M HCl, and the remaining acid required 6.34 mL of 0.010 M NaOH for complete titration. What is the weight % of nitrogen in the protein? MW= 14 a. 3.86 b. 15.1 c. 51.5 d. 5.65 59. How many grams of Cupric (II) Sulfate pentahydrate should be dissolves in a volume of 500 ml to make 8 X 10-3 M solution? MW= 249.54 a. 0.998 b. 9.98 c. 99.8 d. 109.1 60. The molarity of concentrated HCl purchased in the laboratory is approximately 12.1 M. How many mL of this reagent should be diluted to 2 L to make 0.1 M? a. 1.65 b. 6.53 c. 16.53 d. 165.3 61. A solution with a final volume of 500 mL was prepared by dissolving 25 mL of methanol (density= 0.7914 g/mL) in chloroform. Calculate the molarity of methanol in the solution. MW= 32. a. 0.12 b. 1.24 c. 12.4 d. 124 Page 8 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] 62. The above solution (question no.61) has a density of 1.454 g/mL. Find the molality of methanol. a. 0.87 b. 0.77 c. 8.7 d. 7.7 63. What is the use of HgI2 in the preparation of starch TS? a. To increase the solubility of starch b. To impart color c. As a preservative d. To stabilize the pH 64. Process of measuring the actual quantity mass, volume, force, etc. that correspond to an indicated quantity on the scale of an instrument. a. Weighing b. Calibration c. Both a and c d. None of the choices 65. Also known as Eosin Y. a. Dichlorofluorescein b. Tetrabromophenolpthalein c. Tetrabromofluorescein d. Xylenol orange 66. The active fraction of starch which reacts with iodine to form an intense blue color a. Amylopectin b. Amylose c. Glucose d. Sucrose 67. When a reducing analyte is titrated directly with iodine, the method used is called a. Iodometry b. Iodimetry c. Cerimetry d. Permanganometry 68. The 0.1 N iodine solution is standardized using a. Potassium permanganate b. Potassium hydrogen phthalate c. Arsenic trioxide d. Sodium carbonate 69. Iodimetry is an indirect analysis of: a. Oxidizing agent b. Reducing agent c. Acid d. Base 70. Which of the following statement/s is/are correct according to USP 27? I. In azeotropic method of water of analysis toluene is used as solvent. Page 9 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] II. III.

In azeotropic method of analysis toluene and xylene are used as solvents. In azeotropic method of analysis toluene, xylene, and water are used as solvents. a. I only b. I and II only c. I, II, and III d. None of the statement is correct 71. What weight of arsenic trioxide (93.73%) would be used as a sample so that 26.6 mL of 0.1120 N iodine would be needed to titrate it? MW = 197.46 a. 0.14896 g b. 0.4896 g c. 0.1111 g d. 0.9145 g 72. The type of alkaliodal assay where the total alkaloid is determined. a. Ultimate b. Specific c. Proximate d. Extraction 73. Which of the following statement/s is/are correct? I. Method I of water content determination in USP 27 is the azeotropic toluene distillation method. II. Method II of water content determination in USP 27 is the titrimetric method. III. Method III of water content determination in USP 27 is the gravimetric method. IV. Method I of water content determination in USP 27 is the Karl Fischer method. a. I only b. II only c. III only d. IV only 74. Residue on ignition is also called: a. Loss on ignition b. Loss on drying c. Acid-soluble ash d. Sulfated ash 75. Primary standard used to standardized Karl Fischer reagent is: a. Anhydrous sodium carbonated b. Sodium tartrate c. Potassium hydrogen phthalate d. Sodium oxalate 76. Method 1 for determining alcohol-soluble extractives is also known as: a. Hot extraction method b. Cold extraction method Page 10 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] c. Hot compressed method d. Cold compressed method 77. Which of the following statement/s is/are correct I. Iodine value is a quantitative measure of the amount of unsaturated fatty acid in fats. II. Method I of determining iodine value is also known as Hanus method. III. Wij’s method is also a method of determining iodine value. IV. Hubl’s method is official method of determining iodine value. a. I only b. I and II c. I, II and III d. All of the statements are correct 78. Koettsdorfer number is also known as: a. Acid value b. Saponification value c. Ester value d. Iodine value 79. The gram-equivalent weight of sodium oxalate (MW = 134 g/mole) is: a. 67 b. 0.067 c. 0.114 d. 0.026 80. Orthophenanthroline TS is used as indicator in a. Permanganometry b. Ceric sulfate titration c. iodometry d. Iodimetry 81. A sample of Chlorpheniramine maleate weighing 0.502 g was assayed by nonaqueous titrimetry using 22.2 mL of perchloric acid with normality of 0.1125. Calculate the % purity of the sample. Each mL of 0.1 N perchloric acid is equivalent to 19.54 mg of C16H19CLN2. C4H4O4 a. 97.2 b. 72.9 c. 27.9 d. 9.72 82. Calculate the weight of oxalic acid required to prepare 1000 mL of 0.5 N of the solution. MW = 126 a. 36.5 g b. 63.5 g c. 31.5 g d. 23.5 g 83. If 10g of olive oil required 20 mL of 0.0211 N NaOH in the titration of the free fatty acids. What is the acid number of the oil? a. 2.9 Page 11 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] b. 2.4 c. 11.50 d. 115 84. Does the acid value of the above conform with the official requirement? (In 10g of olive oil, the specification is 1.4°C in the 9 readings of the 3 rabbits None of the above The ester value determination of substance is applicable to the following except: Fats Volatile oil Alcohols Fatty oils In Gas chromatography, the results of the assay is expressed in: Retention on the column Rf value Volume of the gas used Adsorbent The process by which the exact concentration of a solution is determined by: Neutralization Standardization Hydration Titration The infrared region of the spectrometer used to identify a substance uses a wavelength range of: 3-5 µm 380-780 µm 200-380 µm 15-300 µm The primary standard used to standardize Karl Fischer reagent is: Sodium carbonate anhydrous Potassium biphthalate sodium tartrate dihydrate sodium bicarbonate the molecular weight of sulfuric acid is 98. Its equivalent weight is: 98 49 0.098 0.049 The type of ash where sulfuric acid used to whiten the ash is: acid insoluble ash sulfated ash loss on ignition Page 25 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] d. ROI The oil from peppermint can be determined by using: a. Cassia flask b. Bobcock bottle c. Pycometer d. Titration 188. The molecular weight of NaOH is 40. How many grams of sodium hydroxide pellets are needed to make 500 mL of 1.5 N solution? a. 20 b. 30 c. 40 d. 60 189. Using spectrophotometer to measure the concentration of a sample, the following data were obtained: absorbance (A) of the standard solution was 0.55. A of the sample was 0.58. Concentration of the standard used was 16.5 mcg. The concentration of the sample was: a. 15.5 mcg b. 17.55 mcg c. 17.40 mcg d. 15.9 mcg 190. Nephelometry is based on the measurement of light that is ______ by the particles of a suspension. a. Reflected b. Absorbed c. Transmitted d. Absorbed 191. The type of chromatography where the cellulose of the filter paper is used as the adsorbent is: a. Column b. Paper c. TLC d. Gas 192. All of the following are optical devices except: a. pH meter b. Spectrophotometer c. Colorimeter d. Filter photometer 193. Which of the following is an oxidizing agent? a. Ascorbic acid b. KMnO4 c. Sodium thiosulfate d. Sodium nitrite 194. A method used to assay Vitamin B12 and Ca panthothenate is by: a. Iodimetry

187.

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Quality Control and Quality Assurance Questions [PINK PACOP]

195.

196.

197.

198.

199.

200.

201.

202.

b. Micro-bio/ turbidimetric c. Fluorometry d. Iodometry The assay of aldehyde content in volatile oil may be by: a. Gravimetric b. Bisulfite c. Hydroxylamine d. B and C One of the fundamental laws in spectroscopy is: a. Law of mass action b. Beer’s law c. Boyle’s law d. Newton’s law Gas chromatography is utilized in the separation of: a. Volatile component in a liquid mixture b. Amino acids c. Blood components d. A and B In column Chromatography, the separation of the sample mixture into a series of narrow bands in a column is called: a. Chromatogram b. Eluent c. Development d. A and B In spectrometry, when a test solution is prepared and observed identically with a reference standard, they are called: a. Isomeric substance b. Similar solutions c. Similar preparations d. B and C Beer’s plot in spectrometry is prepared to determine: a. Absorbance of the sample b. Wavelength to be used c. Blank d. Concentration of the drug substance A one percent (1%) solid in liquid solution is officially (USP) understood as: a. 1g in 100 mL b. 100 mg in 1 mL c. 10g in 1000 mL d. 10 g in 1 L When packaging and storage requirements specifies a “well close container” it is understood that; a. Contents are protected from extraneous solids b. Contents are protected from extraneous solids and liquids Page 27 of 40

Quality Control and Quality Assurance Questions [PINK PACOP] c. Contents are protected from extraneous solids, liquids and vapors d. Contents are protected from extraneous solids, liquids, vapors and gas 203. When packaging and storage requirements specifies a “tight container” it is understood that; a. Contents are protected from extraneous solids b. Contents are protected from extraneous solids and liquids c. Contents are protected from extraneous solids, liquids and vapors d. Contents are protected from extraneous solids, liquids, vapors and gas 204. When packaging and storage requirements specifies a “hermetic container” it is understood that; a. Contents are protected from extraneous solids b. Contents are protected from extraneous so...