Tutorials - Tutorial 1 and 2 notes PDF

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Drugs Affecting the Nervous System - Tutorials Tutorial 1 1. Which of the following statements about the neurotransmitter NA is INCORRECT? a) Dopamine is a precursor molecule for NA synthesis. b) Adrenaline is a precursor molecule for NA synthesis. c) L-DOPA is a precursor molecule for NA synthesis. d) Monoamine oxidase can metabolise NA. e) COMT can metabolise NA. 2. Ganglionic transmission within the ANS is mediated by: a) ACh acting on muscarinic receptors. b) ACh acting on nicotinic receptors. c) NA acting on α-2 adrenoceptors. d) NA acting on nicotinic receptors. 3. Which one of the following statements about the neurotransmitter ACh is INCORRECT? a) ACh is degraded by the enzyme AChE. b) ACh is always released from pre-ganglionic parasympathetic neurons. c) ACh is always released from post-ganglionic sympathetic neurons. d) ACh is always released from pre-ganglionic sympathetic neurons. 4. Co-transmission describes the process whereby: a) Different neurotransmitters produce the same functional effects. b) A single neuron can release more than one neurotransmitter substance. c) Different neurotransmitters produce synergistic effects. d) A neurotransmitter can produce an enhanced effect by activating two or more signal transduction mechanisms. 5. Reserpine can be used to demonstrate co-transmission in sympathetic nerves because: a) Reserpine interferes with the storage of NA. b) Reserpine blocks the nerve AP in sympathetic nerves. c) Reserpine blocks prejunctional α-adrenoceptors. d) Reserpine interferes with the storage of NA. e) ACh is always released from somatic motor neurons. Short Answer: Discuss the experimental evidence supporting the concept of co-transmission by sympathetic nerves. In your answer compare and contrast the processes of chemical transmission involving "classical" and "non-classical" transmitters. Classical transmitters: Non-classical transmitters:...