WEEK4 HEMA 2 Rationale PDF

Preview

Summary

WEEK 4: HEMA 2 RATIONALE1. Answer: hemorrhage Bleeding and chronic inflammation are induced when procoagulant is absent Excessing clot – DVT, cardiovascular disease 2. Answer: Tissue factor – initiates coagulation Anticoagulant – prostacyclin, heparan sulfate, nitric oxide o Prostacyclin – secreted ...

Description

MTAP 412 WEEK 4: HEMA 2 RATIONALE

1. • • •

Answer: hemorrhage Bleeding and chronic inflammation are induced when procoagulant is absent Excessing clot – DVT, cardiovascular disease

4. •

Answer: providing a smooth inner surface of the blood vessels

•

Answer: lymphocytes and monocytes together endothelial cells initiate the release of tissue factor

•

Answer: 16 clotting factors; majority are produces in the liver

5. 2. • •

Answer: Tissue factor – initiates coagulation Anticoagulant – prostacyclin, heparan sulfate, nitric oxide o Prostacyclin – secreted by EC to repel the platelet to adhere on the endothelium o Heparan sulfate – secreted by EC that activates the antithrombin o Nitric oxide – secreted by EC to induce vasodilation o TFPI -inactivates factor VII

6.

•

•

7.

3. •

Answer: inhibits platelets to adhere in the endothelium

• • • •

Answer: factor X Factor VII – stable factor Factor XI – plasma thromboplastin antecedent Factor XII – Hageman factor

MTAP 412 WEEK 4: HEMA 2 RATIONALE

11.

8. • •

• •

Answer: antihemophilic factor (factor VIII) – labile factor Stable factor, Christmas factor and Hageman factor are serine proteases

Answer: protein C Protein S is a co-factor of protein C to regulate the activated factor V and VIII

• 9. • •

Answer: factor II Factor I – has the highest concentration in plasma

12. •

Answer: none of the choices are correct (they are all procoagulants)

•

Answer: produced primarily in hepatocytes activated form can be inactivated by protein C

•

Answer: factor XII, HMWK, prekallikrein (involve in intrinsic pathway)

10. •

Answer: Factor II 13.

14.

•

15.

MTAP 412 WEEK 4: HEMA 2 RATIONALE •

Answer: factor XII

18. •

Answer: protein C deficiency may cause massive thrombus to neonates

• •

Answer: factor XIa, IXa, and Xa Factor VIIa inactivates by TFPI

•

Answer: both statements are correct

•

Answer: tissue plasminogen activator is the only one being produced by endothelium

16. •

Answer: factor XII or hemophilia C

19. 17. •

Answer: ZPI

20.

21.

•

• •

22.

•

MTAP 412 WEEK 4: HEMA 2 RATIONALE Answer: alpha 2-antiplasmin (produced in the liver)

26. • • •

•

Answer: PT and APTT (lab test for common pathway) Intrinsic pathway: APTT Extrinsic pathway: PT

23. • •

Answer: factor I Adhesion problem - vWF

27. • •

Answer: PT and APTT Thrombin time – assess the decrease level of fibrinogen together with fibrinogen level

• •

Answer: increased risk of thrombosis Protein C acts on factor V and VIII

•

Answer: 50-186%

24. •

Answer: activated protein C and protein S

28.

25. •

Answer: factor IXa and factor X

29.

•

MTAP 412 WEEK 4: HEMA 2 RATIONALE •

APTT is prolonged in heparin while PT is normal

33. •

Answer: factor V

•

Answer: prolonged tourniquet application causes hemoconcentration therefore may cause shortened PT

•

Answer: 5x of inversion

• •

Answer: 9:1 Citrate in tube – 3.2%

•

Answer: 24 hours

•

34.

30. • •

Answer: classical hemophilia (factor VIII deficiency) Bleeding time and platelet count – assess primary hemostasis disorder

35.

31. •

•

Answer: soda lime glass – may activate the platelets and coagulation factors due to its negative charge Most preferred: plastic blue-stopper

36.

37.

32. • • •

Answer: normal Coumadin s used for patients who have possible thrombosis PT is prolong in coumadin

MTAP 412 WEEK 4: HEMA 2 RATIONALE

•

43. • •

Answers: deep vein thrombosis D-dimer is one of the degradation products during fibrinolysis

•

Answer: collagen

38. • • •

Answer: thromboplastin, platelet poor plasma, calcium chloride Platelet rich plasma is used in platelet aggregometry Kaolin and ellagic acid are serving as activators for APTT 44.

39. •

Answer: APTT

• 40. •

Answer: reptilase time

45. • •

Answer: arachidonic acid Ristocetin is for von Willebrand disease

•

Answer: chromogenic

41. •

Answers:...