1. History of Immunology PDF

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IMMUNOLOGY SEROLOGY HISTORY OF IMMUNOLOGY NAME OF THE SCIENTISTS VOLTAIRE EDWARD JENNER LOUIS PASTEUR ALBERT CALMETTE CAMILLE GUERIN JONAS SALK ALBERT SABIN MAX THEILER IAN FRAZER ERNST HAECKEL ALMOTH WRIGHT, STEPHEN DOUGLAS, JOSEPH DENYS ELIE METCHNIKOFF EMIL VON BEHRING KITASATO JAMES GOWAN YEAR 1...

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IMMUNOLOGY & SEROLOGY

HISTORY OF IMMUNOLOGY NAME OF THE SCIENTISTS VOLTAIRE EDWARD JENNER LOUIS PASTEUR ALBERT CALMETTE & CAMILLE GUERIN JONAS SALK & ALBERT SABIN MAX THEILER IAN FRAZER ERNST HAECKEL ALMOTH WRIGHT, STEPHEN DOUGLAS, & JOSEPH DENYS ELIE METCHNIKOFF EMIL VON BEHRING & KITASATO JAMES GOWAN

YEAR 1773 1798 1880-1881 1921

DISCOVERY reported on Chinese practice of Variolation discovered Smallpox vaccine by using Cowpox virus discovered live, attenuated vaccine against Chicken cholera, Anthrax, & Rabies developed 1st successful vaccine against Tuberculosis

Late 1930 2005 1862

developed Polio vaccine developed Yellow fever vaccine discovered Human Papilloma Virus (HPV) vaccine Phagocytosis

1903

KARL LANDSTEINER ALIC ISAACS & JEAN LINDEMANN ALEXANDER FLEMMING E. DOUNAL THOMAS & JOSEPH MURRAY ROBERT KOTCH P. PORTIER & CHARLES RICHET VON PIRQUET & SCHICK GRUBER & DURHAM FERDINAND WIDAL PFEIFFER & BUCHNER JULES BORDET

1883-1905 1890 1924

Cellular theory of Immunity through Phagocytosis Humoral theory of Immunity discovered that Adaptive Immunity is mediated by Lymphocytes

1900 1957 1996-1998 1922 1991 1891 1902 1906 1896 1896 1894-1895 1920

discovered the ABO Blood group discovered Interferons identified the Toll-like receptors Discovered Penicillin & described the action of Lysozymes introduced the concepts of Transplantation demonstration of Cutaneous Hypersensitivity Immediate Hypersensitivity—Anaphylaxis describe the relationship of Immunity & Hypersensitivity discovered Agglutination reactions devised an agglutination reaction for the diagnosis of Typhoid fever Complement mediated Cytolysis received Nobel Prize for his pioneering works on Complement worked out the genetics of the Murine Major Histocompatibility Complex (MHC) & generated the congenic strains needed for its biologic analysis an early pioneer in the study of MHC or HLA discovered Immune response genes & collaborated in the first demonstration of MHC restrictions Antibody formation theory worked out the polypeptide structure of the antibody molecule, laying out the groundwork of its analysis by protein sequencing made crucial discoveries about the structure of Immunoglobulin, including the first complete sequence of Ab molecule made studies on Acquired Immunologic Tolerance

GEORGE SNELL

1903

JEAN DAUSSET

1906

BARUJ BENACERRAF

1920

PAUL ERHLICH

1900

RODNEY PORTER

1920-1985

GERALD EDELMAN

1929

PETER MEDAWAR CESAR MILSTEIN & GEORGES KOHLER

1915-1987 1927 1946

NIEL JERNE

1911

ROSALYN YALOW MICHAEL HEIDELBERGER KENDALL SUSUMU TONEGAWA MOSMANN

1921 1888-1991 1930-1935 1939 1986 2001

PETER DOHERTY & ROLF ZINKERNAGEL

1996

LUC MOTAIGNER

1980

ROBERT GALLO

1980

JOYCE ANN S. MAGSAKAY

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discovered Opsonins & describe its relation to Phagocytosis

developed the Hybridoma technique of Monoclonal Antibody formation developed the Hemolyic Plaque Assay & several important immunological theories including an early version of Clonal selection developed Radioimmunologic Assay (RIA) of peptide hormones developed the Quantitative Precipitin Assay conducted Quantitative Precipitin Assay studies on Antigen-Antibody molecules Discovered Antibody diversity & TCR diversity Th1 vs. Th2 model of T-helper function discovered the FOX3p, the gene directing regulatory T-cell development work on the mechanism of cellular immune response mediated by T-cells towards virally infected cells isolated a retrovirus from a non-immune deficient homosexual man with Lymphadenopathy & called it as “Virus Lymphadenopathy Associated Virus” (LAV) renamed the retrovirus as “Human Immunodeficiency Virus” (HIV)

BS MEDICAL LABORATORY SCIENCE

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OLFU VALENZUELA...