Ch 25 DNA Metabolism crossoword AK PDF

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Ch 25 DNA Metabolism Crossword 1 2

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Across 2. Parental DNA strand serves as a ______ for DNA elongation during replication 4. This type of nuclease enzyme makes cuts within a DNA sequence. 6. This isoform of DNA polymerase in eukaroytic organisms has polymerase and primase activity does not have proofreading activity 9. This type of DNA repair uses specific DNA glycosylases that creates AP sites; _____ excision repair 13. The _____ of the base-pair accounts for the high fidelity of the DNA polymerase enzyme 14. This type of protein is used to regulate the cell cycle in eukaryotic organisms 18. If unrepaired, a lesion becomes a _______ 21. This enzyme is the first enzyme to bind to the OriC site to initiate E. coli replication

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Down 1. Synthesis _____ occurs by the addition of new nucleotides to the 3'-end (3'-OH) 3. Synthesis of this strand of DNA is made continuously as the replication fork advances 5. Lagging strand synthesis is accomplished via synthesis of small fragments of DNA called _______ fragments 7. This type of DNA recombination occurs when two DNAs exchange sequence information through similar sequences 8. DNA replication accomplished by this type of mechanism 10. This enzyme makes RNA primers to help initiate DNA replication 11. This subunit of DNA Pol III enhances the enzyme's processivity 12. This serves as a good leaving group for the

22. This site in the DNA polymerase is where the newly base pair resides when the polymerase moves forward 23. The diversity within this class of proteins is created by DNA recombination that allows for the immune system to recognize many millions of foreign antigens. 28. Another name for DNA damage 29. This biological process can be used to repair damage to DNA when some segments of DNA rearrange their location 31. This protein functions like bacterial DnaA in the origin recognition complex in eukaryotic organisms 33. This region of the oriC site in E. coli is an A-T rich region that becomes denatured as a result of supercoiling caused by DnaA 35. A gap in the DNA backbone is called this 36. This enzyme uses ATP to unwind the DNA strands 38. This type of reaction is used by DNA ligase to help seal the DNA backbone 40. The 3'-5' exonuclease activity of DNA polymerases serves this function in DNA polymerization 41. This segment of DNA Polymerase I can be separated from its 3'-5' exonuclease activity to generate this fragment of the DNA Polymerase I 42. This scientific group demonstrated that DNA replication occurs by a specific mechanism from their experiment called _______-Stahl experiment 44. This specialized structure at the end of the chromosomes requires a specialized enzyme to synthesize its DNA sequence 45. This specific enzyme is used by E. coli to relieve the topological stress ahead of the replication fork 46. This required protein for DNA replication binds single-stranded DNA (use abbreviation) 47. This short strand of complementary DNA/RNA to the template is required by DNA polymerase to initiate replication 48. This enzyme seals the nicks between successive nucleotides on the same strand of DNA

incoming dNTPs in DNA growing strand synthesis 15. This isoform of DNA polymerase is the principal replication polymerase (Use abbreviation) 16. Pyrimidine dimers produce large distortions to DNA and therefore are repaired by ______ excision repair 17. This class of enzyme is used by E. coli to separate the interlinked, newly replicated DNA chromosomes (use as one word) 19. True or False: DNA replications in the 5'-3' direction and is continuous 20. This type of DNA damage occurs from the incorporation of incorrect nucleotides 24. This atom helps make the 3'-OH more nucleophilic in the active site of DNA polymerase (use abbreviation) 25. The number of nucleotides added before the DNA polymerase dissociates is called this 26. This type of mutation has no effect on gene function 27. This enzyme/protein serves as the helicase that unwinds DNA during DNA replication and serves as the attachment point for DNA Pol III 30. This type of DNA recombination occurs when short DNAs move from one chromosome to another 32. The complex of enzymes and proteins that are required for DNA replication is called this 34. This drug functions as a DNA polymerase inhibitor in HSV 37. This enzyme methylates adenine residues in the palindromic GATC sequences of the E. coli origin 39. This scientist discovered DNA Polymerase I (last name) 43. This strand is elongated away from the replication fork during DNA replication 44. This protein is associated with the termination sequences in the E. coli genome to cause the replication fork to stop...