My Dog is Broken - mandatory assignment for participation points PDF

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mandatory assignment for participation points...

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My Dog is Broken! A Case Study in Cell Signaling- Answers Assignment 1 Review Email and then write an email to Tess identifying the first messenger that starts the signal transduction in the smooth muscle cell, the likely second messenger, and finally the cellular response caused by the cell signaling cascade. Explain why the arrows go from small to bigger. Also identify whether the receptor that starts the cell signaling pathway is in the plasma membrane or intracellular. What is the first messenger that initiates the signal transduction cascade in the smooth muscle cell? Nitric Oxid What is the second messenger in the signal transduction cascade within the smooth muscle cell? cGMP Is there more than one second messenger in the signal transduction cascade initiated by NO in the smooth muscle cell? Yes What is the response generated by the signal transduction cascade in the smooth muscle cell? Relaxation of the smooth muscle The receptor that receives the first messenger and initiates the cell signalling pathway in the smooth muscle cell is .... An intracellular receptor The arrows increasing in size along the signalling pathway denotes which of the following? Amplification along the signaling pathway

Assignment 2 Review email and then answer the following questions: 1. Melody said that ginseng enhances erection. What effect would you expect ginseng to have on nitric oxide? Why? Ginseng can enhance erection because it will create more nitric oxide. By creating more nitric oxide, you make a stronger signal, and it is more likely to work. 2. Knowing that Melody said Viagra also enhances erection, what effect would you expect it to have on PDE? Why? PDE 5 breaks down cGMP. But there is a PDE 5 inhibitor that keeps it from doing that. So, Viagra (wait for this) inhibits the inhibitor! That way cGMP can be broken. 3. If neither chemical works what protein(s) would you suspect is “broken”?

If neither ginseng or Viagra work odds are that the PKG is the one having problems....