Alchole 4 - MMED3933 PDF

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MMED3933...

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xplain how alcohol metabolism can perturb lipid metabolism, increase fatty acid accumulation and triglyceride synthesis leading to changed in lipid profile in plasma - Beta oxidation is inhibited because it produces NADH - End product of alcohol metabolism is acetate which is readily converted to acetyl coA - Acetyl coA is the starting point for fat synthesis and ketone synthesis - Acetyl coA carboxylase is active because of the high amounts of acetyl coA and inhibition of oxidation - Malonyl coA is produced from reaction and inhibits beta oxidation by preventing fatty acids from entering mitochondria (site of beta oxidation) (carnitine palmotyl transferase 1) - Dyslipidemic - Increased lipid synthesis - Increased peripheral lipolysis due to hormonal distrubances (adrenaline) - Inhibition of glycolysis at g3p step causes build up of g3p which is used for trig...