BIO 218 Syllabus Wi2021 PDF

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Syllabus_Bio218 Winter 2021

BIO 218: Principles of Molecular Biology 4 Credits Winter 2021

Lecture –Tuesday/Thursday 9:30-11:00 am (Remote Synchronous) Delivery via ZOOM at the designated lecture time. Course Instructor: Laura E. Duwel, Ph.D. [email protected] Office Hours via Zoom: TBD

Recitations: Sec 001 FridayHHMI, 1-2Betzig pmLabvia Zoom Sec 002 Friday 11-12 pm via Zoom Sec 003 Friday 2-3 pm via Zoom

Required Text Principles of Genetics, Snustad 7th Edition (ISBN 9781118875896) The 6th edition will suffice as well. There are ebook and pdf versions available on-line.

Course Rationale and Description BIO 218 is a course in which we will explore the principles of molecular biology. The course is designed to familiarize you with the details and concepts revolving around molecular biology’s “central dogma”. Specifically you become familiar with chemical nature of DNA and RNA, the molecular structure of DNA and chromosomes, DNA replication, transcription, translation, the definition of a gene, and how gene expression is regulated. We will also discuss the current status of molecular biology in society throughout the course. Given that this is a course that covers the fundamentals of molecular biology, mastery of the material in the lecture is required for understanding of more advanced courses offered in the department. This syllabus is tentative and may be altered during the term. In addition to lecture, there are weekly recitation meetings for one hour. In these small group settings lecture material will be revisited along with homework assignments and quizzes.

Commitment to Diversity, Equity, and Inclusion in Education The Drexel Biology Department aims to create positive learning environments for students, both inside and outside of the classroom. We support the diversity of thoughts, perspectives and experiences each student brings and honor each student's identity (including race, ethnicity, gender, socioeconomic status, sexuality, religion and disability). We encourage you to share information regarding pronouns, religious and cultural holidays, or accommodations that will assist your instructor to foster a supportive and inclusive environment. As educators, we commit to our own ongoing growth and education in order to best promote respect and integrity within our diverse community. If you have any questions or concerns please contact your instructor, alternatively anonymous feedback about your experiences can be provided through the CoAS Diversity, Equity, and Inclusion Open Line: https://drexel.qualtrics.com/jfe/form/SV_9Y4kXUY30FdldxX

Course Objectives: The completion of this course, students will be able to: 1

Syllabus_Bio218 Winter 2021 1. Describe in detail the chemical structure of nucleic acids 2. Describe how DNA functions as genetic material 3. Describe the goal of DNA replication as well as the details 4. Describe goal of transcription as well as the details 5. Describe goal of translation as well as the details 6. Understand the molecular mechanisms of mutation and mutation repair 7. Understand methods of gene regulation for prokrayotes and eukaryotes 8. Understand the genetic regulation of development in vertebrates Academic Expectations  Attendance in recitation is required. 1% will be deducted for all unexcused absences. We will be meeting via Zoom for Recitations and groups will work on homework in breakout rooms during the session. The answers to the HW will be posted as a powerpoint after the HW has been submitted.  Attendance during the Zoom lectures is highly recommended, but the session will be recorded and posted.  Students are to be conversant with the policies, schedule, and requirements of this course as set out in this syllabus.  Students are to have read the assigned material prior to lecture and recitation.  Students are to be prepared for each lecture and recitation prior to meeting.  Students are expected to be engaged in the lecture during attendance. Resources  Lecture slides are posted on the Bio 218 LEARN page as Powerpoint files. You should take notes during the lecture to help you as you review for exams.  Important Terms. A list of important terms is available on LEARN for each chapter. Students are responsible for knowing the definitions for these terms because mastery of these terms is an essential aspect of this course. Students will be assessed on their knowledge of these terms in quizzes and examinations.  Chapter HW. Chapter questions will be assigned with each chapter as HW. These questions will be completed during recitation.

Assessments Assessment Quizzes Ch 9 Mini-Test

% of final grade 20% (2% each) 4%

Mid-Term Exam I

20%

Mid-Term Exam II

20%

HW/Participation

14% (2% each) 22% (Chapters 18 & 22 + cumulative)

Final Exam



Location On-line. Quizzes will be open Friday until Monday at 11:59 pm. Week 3 Tues 12:00 pm – Wed 11:59 pm Tues Wk 5 via LEARN Respondus w/Webcam Tues Wk 8 via LEARN Respondus w/Webcam Recitations via Zoom Attendance required. TBD

Recitation attendance is mandatory. 1% will be deducted for all unexcused absences. During recitation you will be working in groups of three to answer the HW questions. Instructor must be notified within 24 hrs of the missed recitation in order for a make-up to be considered. 2

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Quizzes will be given on-line after recitation in the weeks indicated on the schedule for a total of 10 quizzes. Quizzes will be open from Friday to Monday at 11:59 pm. The material included on the quiz will be drawn from lecture and reading material from the weeks’ lecture as well as the terms and HW questions. There is no make-up for missed quizzes. Quiz average will be pro-rated for University approved excuses only and is at the discretion of the instructor. HW/Participation will be assessed in recitation each week. Completing the homework and participating in the discussion about the HW assignments will be assessed. During the recitation you will be placed into groups and each group will be responsible for completing the assigned HW. This will contribute to your HW/participation grade for the course. Each HW will be worth 1%. In addition, each student will be assessed (1%) for participation in the discussion and completion of the HW. Thus, each HW/Recitation session will be worth 2% of the grade for a total of 14% for the term. If there are group members not participating in the discussion and completion of the HW, they may forfeit their participation points. It is expected that students come prepared to recitation having read the chapter and reviewed the lecture slides. These HW questions will not be “graded”, but will be assessed for completion. However, if groups are not adequately explaining answers, points may be deducted. The HW questions for each week will be posted on LEARN on Monday to allow students to review the HW questions as we work through the chapter for the week. Groups should try to complete the HW during recitation in their breakout rooms, however, HW must be submitted on LEARN by 11:59 pm on Sunday. On the following Monday, a slide show recording will be posted to review the HW. The weeks when homework is not explicitly assigned, you will still be expected to participate in recitation as part of review for any upcoming exam. Examinations. A multiple choice, fill-in the blank and/or short answer format will be utilized. Exam material is taken from the important terms, HW questions, the textbook, and lecture. Exams will be delivered on-line utilizing Respondus with Webcam capabilities. Midterm I (20%) will cover material from chapters 10-12 and Midterm II (20%) will cover chapters 13 & 17 of the text. The final examination (22%) will be weighted heavily on Chps 18 & 22, but will be cumulative with questions from Chps 9, 10, 11, 12, 13 & 17. Due to the shortened 9 week term, an on-line “mini-test” (4%) will be given for Ch 9 in Week 3. Makeup Exams (format TBD) will only be given to those students who have an University approved excuse for their absence on the day of the exam. Students must notify the instructor within 24 hours of the scheduled exam time to schedule a make-up exam.

Disability Accommodations It is the University's policy to provide a learning environment that provides all students with the opportunity to realize their full potential. Students requesting accommodations due to a disability at Drexel University need to request a current Accommodations Verification Letter (AVL) in the ClockWork database before accommodations can be made. These requests are received by Disability Resources (DR), who then issues the AVL to the appropriate contacts. For additional information, visit the Disability Resources web page, or contact DR for more information by phone at 215.895.1401, or by email at [email protected]. Course Drop Policy Please note that “dropping” a course and “withdrawing” from a course are distinct actions and are governed by different policies. For undergraduate students, courses may only be dropped during the “drop period” lasting from the beginning of the enrollment period through the end of the first week of the quarter (Sunday, 11:59 pm via the web). https://drexel.edu/provost/policies/course-add-drop/ Dropping a course results in the course being removed from the student’s academic record without a “W” appearing on the transcript— 3

Syllabus_Bio218 Winter 2021 specifically, neither the course nor the grade of “W” appears on the student’s transcript. Approval of the instructor is not required to drop a course (but is required to withdraw from a course). Undergraduate students may withdraw from a course during the “withdrawal period” lasting from the beginning of the 2nd week through the end of the 7th week of the quarter. Specifically, the last day to withdraw from a course is the Friday of the 7th week of the quarter. Withdrawing from a course causes both the name of the course and the grade of “W” to appear on the student’s transcript. Before withdrawing from a course, students should consult with the instructor. All students must obtain their advisor’s written authorization before withdrawing from courses. The form for withdrawing from a course can be found at: http://drexel.edu/drexelcentral/courses/adjustments/course-withdraw/ Academic Dishonesty (or Cheating) Cheating is unacceptable behavior. Anyone caught cheating or plagiarizing work will face serious consequences, including failure of the course and reporting to the Office of Student Affairs and Community Standards. Please review the University policy on academic dishonesty at: http://drexel.edu/studentaffairs/community_standards/overview/ Consequences of violations of the academic honesty policy can be found at: https://drexel.edu/studentlife/community_standards/studenthandbook/general_information/code _of_conduct/ Cheating is an extremely serious breach of academic integrity and will be dealt with severely, according to the guidelines set out in the Drexel Students’ Handbook. Portions of this policy have been included below: “Academic Integrity: Violations of the Academic Integrity policy include, but are not limited to: 1. Plagiarism, 2. Fabrication, 3. Cheating, and 4. Academic Misconduct. The intent to violate this policy also represents a violation of this policy.” Definitions and examples of each offense, as well as sanction guidelines, are described below (or at the end of the syllabus). “Sanction Guidelines for Violating the Academic Integrity policy: First/all violations: If an act of academic dishonesty is determined to have occurred, one or more of the following sanctions will be imposed, depending on the severity of the offense:  Reduction of a course grade  An “F” for the assignment or exam  Failure for the entire course  Other action deemed appropriate by the faculty member  Any of the above sanctions with the inability to withdraw. Examples of other action deemed appropriate include, but are not limited to, requiring the student to re-take the exam, re-complete an assignment, or complete an assigned exercise. The decision of the faculty member and the department head shall be reported to the Office of Student Conduct and Community Standards, which is responsible for maintaining student conduct records. The incident will result in an official conduct record for the student(s). Students may also be required to attend or complete an educational activity as determined by the Office of Student Conduct and Community Standards. Second violation: Suspension or expulsion, in addition to any sanction issued from the list above.”  The Department of Biology has a ZERO TOLERANCE policy towards FABRICATION, CHEATING, and ACADEMIC MISCONDUCT. For this reason the Department of Biology has elected to impose the MAXIMUM PENALTY for cases of fabrication, cheating and 4

Syllabus_Bio218 Winter 2021 academic misconduct. IF an act of fabrication, cheating or academic misconduct are determined to have occurred in a course within the department after consultation between the student, faculty member and representative from the department (Department Head, or Assistant or Associate Department Head) the penalty will be FAILURE FOR THE ENTIRE COURSE with the inability to withdraw from the course. This penalty will be applied for first and all violations.  Plagiarism is considered to be equivalent to cheating since you are copying someone else’s work without giving them due credit, and will be dealt with severely. Cases of plagiarism will be dealt with on a case by case basis with the sanction administered to be in accordance with the severity of the plagiarism, but may also result in failure of the course or other sanctions listed above. Academic dishonesty in any form will not be tolerated. This includes cheating, copying, plagiarism, misrepresentation of lab work or any other form of scholastic misconduct. Students accused of misconduct will have an opportunity to present their case, if misconduct has occurred, they will be reported to the Office of Student Affairs and Community Standards. Counseling Center The Counseling Center’s operations are fully remote. Therapists are able to conduct teletherapy using a HIPPA compliant, confidential Zoom platform to preserve our students’ privacy. Through teletherapy therapists will offer support and problem solving techniques to students. The Counseling Center is also able to provide students within Pennsylvania and students residing across state lines with on-going support as licensing restrictions permit. If students do not have access to a laptop with a camera or a smartphone therapists can engage students via phone as long as the student is in a private space. The therapist will discuss ways to ensure privacy before sessions begin. · Students who would like to schedule an appointment with a therapist can email [email protected] or call our number 215-895-1415. Phones are checked hourly. Our oncall after hours emergency assistance will continue to be available to students 215-416-3337. · In addition to individual teletherapy, Counseling Center staff are developing virtual workshops and other self-help modules that students will be able access and download from our website https://drexel.edu/counselingandhealth/ . A valuable digital resource - 7Cups https://drexel.edu/counselingandhealth/counseling-center/7cups/ - is available to all students who want to ‘talk’ anonymously to a listener. Listeners can be fellow de-identified Drexel students or someone else from the 7Cups universe who is able to communicate with students in their own language about a variety of issues. 7Cups also contains self-help modules students can explore and use as needed. · Finally, for students in recovery or seeking support around substance use issues, the Haven https://drexel.edu/counselingandhealth/alcohol-drug-education/haven/ - is hosting Virtual meetings 7 days/wk at 5pm-6pm PST or 8pm-9pm EST at https://www.gotomeet.me/HavenRecoveryMeeting or call in using your phone: +1(872) 240-3412 Access code: 661-666-741

 Course Grading A+ = 97% or >; A = 92 - 96.9%; A- = 90 - 91.9% B+ = 87-89.9%; B = 82 - 86.9%; B- = 80 - 81.9% C+ = 77-79.9%; C = 72 - 76.9%; C- = 70 - 71.9% D+ = 67-69.9%; D = 60 - 66.9%; F = 59.9% or less 5

Syllabus_Bio218 Winter 2021

Schedule (subject to change) Date Weeks 1-2 Week #1

Week #2

Jan 12 Jan 14 Jan 15 Jan 19 Jan 21 Jan 22

Week #3 Jan 26

Week #4

Jan 28 Jan 29 Feb 2 Feb 4 Feb 5

Topic DNA Structure - Recorded *Mini-Test Ch 9 in Week 3 Replication of DNA and Chromosomes Replication of DNA and Chromosomes Quiz #1 and HW (Ch 10) Transcription and RNA Processing Transcription and RNA Processing Quiz #2 and HW (Ch 11) Translation and the Genetic Code *Mini-Test Ch 9 in Week 3 (Tues 12:00 pm - Wed 11:59 pm) Translation and the Genetic Code Quiz #3 and HW (Ch 12) Mutation, DNA Repair and Recombination Mutation, DNA Repair and Recombination Midterm Review and Review Quiz #4 Midterm Exam I (Tuesday Week 5)

Text Chapter 9 Chapter 10 Chapter 10 Chapter 11 Chapter 11 Chapter 12

Chapter 12 Chapter 13 Chapter 13

Chps 10, 11, Feb 9 12 Feb 11 Regulation of Gene Expression in Prokaryotes Chapter 17 Quiz #5 and HW (Ch 13) Feb 12 Week #6 Feb 16 Regulation of Gene Expression in Prokaryotes Chapter 17 Feb 18 Regulation of Gene Expression in Prokaryotes Chapter 17 Quiz #6 and HW (Ch 17) Feb 19 Week #7 Feb 23 Regulation of Gene Expression in Eukaryotes Chapter 18 Feb 25 Regulation of Gene Expression in Eukaryotes Chapter 18 Feb 26 Midterm Review and Review Quiz #7 Week #8 March 2 Midterm Exam II (Tuesday Week 8) Chps 13 & 17 March 4 Regulation of Gene Expression in Eukaryotes Chapter 18 March 5 Quiz #8 and HW (Ch 18) Week #9 March 9 Genetic Analysis of Development in Vertebrates Chapter 22 March 11 Genetic Analysis of Development in Vertebrates Chapter 22 March 12 Quiz #9 and HW (Ch 22) Exam March 15 Exam Review and Review Quiz #10 Chps 18 & 22 Week -March 20 Final = Ch 18 & 22 + Cumulative (22%) + Cumulative This syllabus is subject to change during the term. *Mini-Test (4%) for Ch 9 will be given in Week 3 on-line from Tues 12:00 pm – Wed 11:59 pm. This min-test will be from recorded lectures due to the shortened 9 week term for Winter 2021. Notice: Appropriate Use of Course Materials It is important to recognize that some or all of the course materials provided to you may be the intellectual property of Drexel University, the course instructor, or others. Use of this intellectual property is governed by Drexel University policies, including the IT-1 policy found here: https://drexel.edu/it/about/policies/policies/01-Acceptable-Use/ Briefly, this policy states that course materials, including recordings, provided by the course instructor may not be copied, reproduced, distributed or re-posted. Doing so may be considered a breach of this policy and will be investigated and addressed as possible academic dishonesty, among other potential violations. Improper use of such materials may also constitute a violation of the Week #5

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Syllabus_Bio218 Winter 2021 University’s Code of Conduct found here: https://drexel.edu/cpo/policies/cpo-1/ and will be investigated as such.

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