Cancer: Last year PDF

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PROGRAMMES: BSc (Hons) Pharmaceutical Science BSc (Hons) Pharmaceutical Science with Professional Studies BSc (Hons) Biomedical Science BSc (Hons) Biomedical Science with Professional Studies BSc (Hons) Biochemistry BSc (Hons) Biochemistry with Professional Studies BSc (Hons) Biochemistry with Studies in USA

CANCER: BENCH TO BEDSIDE PI TIME: 14:00- 17:00

Section A — answer ALL questions 1.

Inhibition of oncogenic signalling pathways is a therapeutic strategy for the treatment of cancer. Describe one of these strategies, and explain how it aims to inhibit the growth of cancer cells. (10 marks)

2.

Provide an explanation of the epithelial-to-mesenchymal (EMT) transition and identify the hallmark of cancer that is mainly affected by it. (10 marks)

3.

What is AflatoxinB and why is it highly carcinogenic?

4.

Describe the role of tumour-associated macrophages in tumour development, with a specific focus on the traits for malignancy promoted by macrophages.

(10 marks)

(10 marks) Section B — answer TWO questions 1.

2.

3.

(30 marks)

What is the link between inflammation and cancer? Describe the mechanism of action of BH3 mimetics, and discuss how this treatment strategy can be used for the treatment of cancer. (30 marks)

Many chemotherapeutic drugs aim to cause apoptosis in cancer cells. Describe the pathways which control apoptosis, and discuss some

techniques which can be used at the laboratory bench to measure apoptosis in cancer research.

(30 marks) 4.

Describe the role of BRCAI and BRCA2 in DNA repair and explain their contribution to cancer. (30 marks)

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