NU636 Quiz 1 PDF

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Quiz one in NU636....

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NU636 Quiz 1

1.A type B adverse drug reaction (ADR) is one that is unrelated to the pharmacologic action of the drug. They are precipitated by secondary pharmacologic actions of the drug, may be unpredictable, and may or may not be dose dependent. ADRs observed by practitioners should be reported to the FDA through which program? Vaccine Injury Program NIH Clinical Trial Monitoring Program MedWatch Program Patient Injury Program 2. Your patient has undergone genetic testing and found to have a

CYP2D6 polymorphism poor-metabolism phenotype. You know that the tricyclic anti-depressant medications are metabolized by the CYP2D6 enzyme pathway. You plan on prescribing amitriptyline for your patient for their depression. A starting dose of amitriptyline is 50 - 100mg daily at bedtime. Given the patient's poor metabolizer phenotype, which of the following doses of amitriptyline would be the appropriate dose for the patient to be started on? 25mg 500mg 100mg 200mg 3. Studies show this herb stimulates phagocytosis while increasing respiratory cellular activity and mobility of leukocytes. Uses include treatment of skin conditions and the common cold. The herb is which of the following? Echinacea Uva Ursi Kava Kava Valerian 4. Examples of drug-disease interactions include the following except: 5. After a drug is administered the concept of pharmacokinetics

encompasses which of the following actions on the drug?

Drug Drug Drug Drug

absorption, distribution, metabolism and excretion ingestion, utilization and excretion absorption, utilization and excretion distribution, utilization and excretion

6. Ethnicity plays a role in both the pharmacokinetic and

pharmacodynamic responses in patients. An example of this concept is Minimal Minimal Minimal Minimal

response response response response

of of of of

Anglo-Americans to ACEI Irish-Americans to ACEI African Americans to ACEI Italian Americans to ACEI

7. The degree to which a drug is attracted to a receptor displays the level of affinity the drug has for that receptor. Not all drugs with an affinity for a receptor elicit a response. A drug with an affinity to a receptor that does not elicit a response is referred to as an: Pro-drug Agonist Inactive drug Antagonist 8. Alcohol ingestion places a patient at great risk for CNS depression when they are concurrently taking which of the following medications? NSAIDS Muscle relaxers Antibiotics PPIs 9. A male patient comes in for evaluation of symptoms suggestive of BPH. On exam you note an enlarged, smooth prostate. His PSA is 0.7ng/ml (normal...