BIO 102 Lab 9 Pedigree Homework PDF

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Bio 102L

Lab 9

Lab 9: Pedigree Homework In this file, use what you’ve learned about pedigrees, Punnett squares, and patterns of Inheritance to answer the following questions

PROBLEM 1 Consider the following pedigree of a family in which some members have an inherited neurological disorder. The disorder is called Huntington’s disease. Pedigree of a Family with Huntington’s Disease

a. What pattern of inheritance does this trait follow? (i.e. autosomal recessive, sex-linked recessive, autosomal dominant, etc?) Autosomal Dominant Trait (1 pt)

b. What is the genotype of I-2? Hh (1 pt)

c. What is the chance that a fourth child of II-4 and II-5 will be affected? Illustrate your answer with the genotypes of the parents and a Punnett square to show how you determined the answer. (1 pt) If they were to have a fourth child then the child would probably not have Huntington’s disease because based on the Punnett square there is a ratio of 2:2 meaning for every two that have it 2 others don’t.

H

h

h

Hh

hh

h

Hh

hh

Bio 102L

Lab 9

PROBLEM 2 Methemoglobinemia (met-H) is a human genetic disorder. People afflicted with this genetic disorder have skin that is blue in color. Yes, it’s a real trait! People with this disorder make a different form of hemoglobin that is blue. Use what you know about pedigrees to Optional: read the article concerning a family from Kentucky with this genetic disorder at the following web site before completing the problem. http://wsrv.clas.virginia.edu/~rjh9u/fugate.html

Pedigree of the Fugate Family

a.

According the pedigree above, what pattern of inheritance is seen in Methemoglobinemia?. (1 pt) Autosomal Recessive Trait

b.

You will be playing the role of genetic counselor. A man and a woman are considering having a child and come to you for information about their chances of their child showing the methemoglobin gene. i. On the next page, draw the pedigree of this man and woman's family back to their grandparents. Use the correct symbols to indicate those with the disorder and known carriers. (4 pts)

Bio 102L

Lab 9

David and Dorene come to your office. They are expecting a child. David’s mother is a blue person, but his father and grandparents were normal color. Dorene is herself a blue person but none of her parents or grandparents were blue people. Make a Pedigree for David and Dorene by dragging the correct symbols on the pedigree frame shown below. If you cannot determine genotype of an individual with the given information, assume he/she is not a carrier. THERE ARE MORE SYMBOLS AT THE RIGHT THAN YOU NEED – YOU MUST MAKE THE CORRECT CHOICES TO MATCH THE DESCRIPTION ABOVE! (4 pts)

Dorene

David

??

Choose from the symbols below for your pedigree, then click and drag them to the place in the pedigree where they belong.

Bio 102L

Lab 9

H

H

H

HH

HH

h

Hh

Hh

ii. Use the genotypes of the two parents to determine the probability that their first born child will have the disorder, with the use of a Punnett Square. (1 pt)

50% chance their baby will have methemoglobinemia iii. What is the probability that their second child will have the disorder? (1 pt)

25% chance their second baby will have methemoglobinemia...