Lecture notes - The Habitat and Morphology of Chlamydia trachomatis PDF

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Lecture notes - The Habitat and Morphology of Chlamydia trachomatis Habitat of Chlamydia trachomatis It is an obligate intracellular human pathogens. Humans are the only natural host. It cannot survive outside of a eukaryotic host. Chlamydia trachomatis is transmitted by oral, vaginal or anal sex, and can also be transmitted from mother to newborn during a vaginal delivery. They can cause discharge from the penis, pain and burning during urination, infection or inflammation in the ducts of testicles, and tenderness or pain in the testicles. Habitat and Morphology of Chlamydia trachomatis

The Morphology of Chlamydia trachomatis It is a weak Gram-negative bacteria. It also contains LPS, which helps cause damage to the host’s body. It lacks a peptidoglycan cell wall. It lacks muramic acid that is found in the cell walls of most other bacteria. It is non-sporing. They are non-motile. It has a coccoid or rod shape. They exist in two morphological forms: small infectious elementary bodies 300 nm – 400 nm in diameter and larger replicating reticulate bodies 800 nm – 900 nm in size. The elementary body is the dispersal form, which is analogous to a spore. The dispersal form is about 0.3 um in diameter. The reticulate body divides through binary fission at approximately 2-3 hours per generation. The reticulate body has an incubation period of 7-21 days in the host. The reticulate body contains no cell wall and is detected as an inclusion in the cell.

The Genome of Chlamydia trachomatis It have an extra-chromosomal plasmid. It has a genome that consists of 1,042,519 nucleotide base pairs. It has approximately 894 likely protein coding sequences.

All the isolates are about 7,500 nucleotides long. It has eight open reading frames computer-predicted to code for proteins of more than 100 amino acids....