Chap034 - Prescotts 10th Ed. PDF

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Chapter 34Adaptive ImmunityMultiple Choice Questions1. The immune system normally discriminates between __________ antigens.A. self and nonselfB. B and T cellsC. humoral and cell-mediatedD. primary and secondary responseASM Objective: 05 Microorganisms, cellular and viral, can interact with both hum...

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Chapter 34 - Adaptive Immunity

Chapter 34 Adaptive Immunity

Multiple Choice Questions 1. The immune system normally discriminates between __________ antigens. A. self and nonself B. B and T cells C. humoral and cell-mediated D. primary and secondary response

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.01.01 Contrast host innate resistance with adaptive immunity Section: 34.01 Topic: Adaptive Line of Defense Topic: Antigens and Antibodies Topic: Basic Host Defenses

2. T cells attack A. host cells that have been parasitized by microorganisms. B. transplanted tissue cells from one host to another. C. cancer cells. D. All of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 1. Remember Learning Outcome: 34.01.01 Contrast host innate resistance with adaptive immunity Learning Outcome: 34.01.02 Outline the localization of B and T cells during development Section: 34.01 Topic: Anatomy/Physiology of Defense Topic: Cell-Mediated Response

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Chapter 34 - Adaptive Immunity

3. The humoral immune response defends against _________. A. bacteria B. bacterial toxins C. viruses D. All of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 1. Remember Learning Outcome: 34.01.01 Contrast host innate resistance with adaptive immunity Learning Outcome: 34.01.02 Outline the localization of B and T cells during development Section: 34.01 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Humoral Response (or Antibody-Mediated Response)

4. T cells produce and secrete factors that do not directly interact with invading microorganisms but that augment the body's defense mechanisms. These molecules are called _________. A. antibodies B. cytokines C. immunogens D. augmetins

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.01.01 Contrast host innate resistance with adaptive immunity Learning Outcome: 34.01.02 Outline the localization of B and T cells during development Section: 34.01 Topic: Anatomy/Physiology of Defense Topic: Cell-Mediated Response

True / False Questions

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Chapter 34 - Adaptive Immunity

5. Most antigens are monovalent. FALSE

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.02.01 Predict the types of molecules that can serve as antigens Section: 34.02 Topic: Anatomy/Physiology of Defense Topic: Antigens and Antibodies

6. Each antigen has one antigenic determinant site or epitope. FALSE

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.02.01 Predict the types of molecules that can serve as antigens Section: 34.02 Topic: Anatomy/Physiology of Defense Topic: Antigens and Antibodies

7. Penicillin is a good example of a hapten. TRUE

ASM Objective: 06.03 Humans utilize and harness microorganisms and their products. ASM Topic: Module 06 Impact of Microorganisms Blooms Level: 1. Remember Learning Outcome: 34.02.02 Compare haptens and true antigens Section: 34.02 Topic: Adaptive Line of Defense Topic: Antigens and Antibodies

Multiple Choice Questions

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Chapter 34 - Adaptive Immunity

8. An immune complex resulting from an interaction of antibody with cells or particles which becomes large enough to settle out of solution is called a(n) A. agglutination reaction. B. precipitation reaction. C. hemagglutination. D. ouchterlony double diffusion.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 37.08.01 Explain the consequences of antibody binding of antigen Section: 34.08 Topic: Anatomy/Physiology of Defense Topic: Antigens and Antibodies

9. Adaptive immunity refers to the type of specific immunity that A. develops after exposure to antigen. B. can result from transfer of antibodies from one individual to another. C. can be induced by natural or artificial means. D. All of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.01.01 Contrast host innate resistance with adaptive immunity Section: 34.01 Topic: Adaptive Line of Defense Topic: Basic Host Defenses

34-4 Copyright © 2017 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education.

Chapter 34 - Adaptive Immunity

10. The transfer of antibodies in breast milk is a good example of A. naturally acquired passive immunity. B. naturally acquired active immunity. C. artificially acquired active immunity. D. artificially acquired passive immunity.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 3. Apply Learning Outcome: 34.03.01 Report the methods by which immunity occurs by natural and artificial means Learning Outcome: 34.03.02 Distinguish between the active and passive forms of natural and artificial immunity Section: 34.03 Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Classification of Acquired Immunities

11. A vaccination is a good example of A. naturally acquired passive immunity. B. naturally acquired active immunity. C. artificially acquired active immunity. D. artificially acquired passive immunity.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Objective: 06.03 Humans utilize and harness microorganisms and their products. ASM Topic: Module 05 Microbial Systems ASM Topic: Module 06 Impact of Microorganisms Blooms Level: 3. Apply Learning Outcome: 34.03.01 Report the methods by which immunity occurs by natural and artificial means Learning Outcome: 34.03.02 Distinguish between the active and passive forms of natural and artificial immunity Section: 34.03 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Classification of Acquired Immunities

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Chapter 34 - Adaptive Immunity

12. Botulinum antitoxin produced in a horse and given to a human suffering from botulism food poisoning is an example of A. naturally acquired passive immunity. B. naturally acquired active immunity. C. artificially acquired active immunity. D. artificially acquired passive immunity.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 3. Apply Learning Outcome: 34.03.01 Report the methods by which immunity occurs by natural and artificial means Learning Outcome: 34.03.02 Distinguish between the active and passive forms of natural and artificial immunity Section: 34.03 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Antigens and Antibodies Topic: Classification of Acquired Immunities

13. When an individual's immune system responds to an appropriate antigenic stimulus during the course of daily activities, this is called A. naturally acquired passive immunity. B. naturally acquired active immunity. C. artificially acquired active immunity. D. artificially acquired passive immunity.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 3. Apply Learning Outcome: 34.03.01 Report the methods by which immunity occurs by natural and artificial means Learning Outcome: 34.03.02 Distinguish between the active and passive forms of natural and artificial immunity Section: 34.03 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Classification of Acquired Immunities

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Chapter 34 - Adaptive Immunity

14. Class I and II MHC molecules A. consists of a complex of two protein chains. B. contains alpha-1 and alpha-2 domains that forms an antibody-binding pocket. C. consists of a complex of two protein chains and contains alpha-1 and alpha-2 domains that forms an antibody-binding pocket. D. neither consists of a complex of two protein chains nor contains alpha-1 and alpha-2 domains that forms an antibody-binding pocket.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.04.02 Diagram the host cell receptors that distinguish self from nonself Section: 34.04 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense

15. The major histocompatibility complex directs the production of proteins called A. class I. B. class II. C. class IV. D. both class I and class II. E. both class I and class IV.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.04.01 Define the method by which a host distinguishes itself from nonself (foreign) materials Section: 34.04 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense

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Chapter 34 - Adaptive Immunity

16. Class II major histocompatibility complex molecules are found on all of the following types of cells EXCEPT _________. A. red blood cells B. B cells C. macrophages D. dendritic cells

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 1. Remember Learning Outcome: 34.04.02 Diagram the host cell receptors that distinguish self from nonself Learning Outcome: 34.04.03 Compare the processes by which MHC class I and class II receptors recognize foreignness Section: 34.04 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Cell-Mediated Response

17. Class I major histocompatibility complex molecules are found on ____________ cells. A. all nucleated B. antigen-presenting C. all anucleated D. None of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 1. Remember Learning Outcome: 34.04.02 Diagram the host cell receptors that distinguish self from nonself Learning Outcome: 34.04.03 Compare the processes by which MHC class I and class II receptors recognize foreignness Section: 34.04 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Cell-Mediated Response

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Chapter 34 - Adaptive Immunity

18. Cytotoxic T lymphocytes are distinguished from other lymphocytes by the presence of _________. A. CD8 B. CD4 C. CD19 D. All of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 1. Remember Learning Outcome: 34.04.05 Explain the use of “cluster of differentiation” (CD) molecules to name cells Learning Outcome: 34.05.01 Categorize T cells based on their CD designation Section: 34.04 Section: 34.05 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Cell-Mediated Response

19. If a T cell that has received signal 1 for activation fails to also receive signal 2 it may become _________. A. anergic B. apoptotic C. anuclear D. cancerous

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.05.06 Build a model of the molecular events resulting in T-cell activation Section: 34.05 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Cell-Mediated Response

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Chapter 34 - Adaptive Immunity

20. Which type(s) of antigen-presenting cell can activate T cells? A. Macrophages

B. B cells C. Dendritic cells D. All of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 1. Remember Learning Outcome: 34.04.04 Identify cells that can function as antigen-presenting cells (APCs) Section: 34.04 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Cell-Mediated Response

21. When a presented antigen fragment interacts with the T cell receptor of a helper T cell, the co-receptor that must also participate to finalize recognition is _________. A. CD4 B. CD8 C. MHC I D. All of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.05.05 Connect antigen presentation within MHC receptors and T-cell subset recognition Learning Outcome: 34.05.06 Build a model of the molecular events resulting in T-cell activation Section: 34.05 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Cell-Mediated Response

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Chapter 34 - Adaptive Immunity

22. During activation of a T cell, the cytokine it produces to stimulate its own proliferation is _________. A. interferon gamma B. interleukin 1 C. interleukin 2 D. tumor necrosis factor

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 1. Remember Learning Outcome: 34.05.06 Build a model of the molecular events resulting in T-cell activation Section: 34.05 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Basic Host Defenses Topic: Cell-Mediated Response

23. Superantigens cause A. specific activation of phagocytic cells. B. stimulation of T cells to overproduce cytokines. C. specific activation of phagocytic cells and stimulation of T cells to overproduce cytokines. D. None of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.05.06 Build a model of the molecular events resulting in T-cell activation Section: 34.05 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Cell-Mediated Response

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Chapter 34 - Adaptive Immunity

24. Superantigens exert their damaging effects by A. forming harmful antibody aggregates. B. causing the massive and non-specific release of cytokines by T cells. C. killing large numbers of phagocytic cells. D. All of the choices are correct.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.05.06 Build a model of the molecular events resulting in T-cell activation Section: 34.05 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Cell-Mediated Response

25. Cytotoxic T cells destroy target cells by A. direct killing mediated by activated oxygen species. B. the perforin pathway. C. the CD95 pathway. D. both direct killing mediated by activated oxygen species and the perforin pathway. E. both the perforin pathway and the CD95 pathway.

ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or detrimental ways. ASM Topic: Module 05 Microbial Systems Blooms Level: 2. Understand Learning Outcome: 34.05.02 Contrast the biological functions of T-cell subsets Section: 34.05 Topic: Adaptive Line of Defense Topic: Anatomy/Physiology of Defense Topic: Cell-Mediated Response

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Chapter 34 - Adaptive Immunity

26. In humans, the antigen-presenting cells include all of the following EXCEPT _________. A. B. C. D.

eosinophils dendritic cells macrophages B cells

ASM Objective: 05.04 Microorganisms, cellula...